![]() In the ND group > 130% EBCage, the ND rate was higher during the first night collection and osmotic excretion was significantly higher overnight. Patients with higher ND (100–129% and > 130% EBCage) had higher daytime volumes and less pronounced circadian rhythm. ResultsĪll groups maintained circadian rhythm for diuresis and diuresis rates. Patients were subdivided into three groups according to nocturnal diuresis (ND) and Expected Bladder Capacity (EBCage) ratio: (a) 130%. Urine volume, osmolality, and creatinine were measured. Circadian rhythms were evaluated by a 24-h urine collection in 8 timed portions (4 day, 4 nighttime) at in-home settings. Retrospective analysis of 403 treatment-naïve children 5–18 years with severe enuresis (> 8 nights/2 weeks). This study aims to investigate the diuresis and solute excretion in treatment-naïve patients with or without NP, with emphasis on circadian rhythms. Nevertheless, data in treatment-naïve populations with information on timing overnight are sparse. Solute handling and osmotic excretion have been investigated in the past, especially in refractory patients. ![]() This suggests that NP may not only be related to vasopressin, but that other kidney components play a role. A substantial percentage of patients do not respond to desmopressin. Nocturnal polyuria (NP) due to a suppressed vasopressin circadian rhythm is a well-documented pathogenetic mechanism in enuresis, mainly studied in monosymptomatic enuresis.
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